Provera challenge weight gain Author(s): Kaushik, Neeru | Abstract: Finding a method of contraception that is both convenient and effective has been a challenge faced by women of reproductive age for many years. and • if taking the medicine will start your period. This medicine is available only with your doctor's prescription. Jun 24, 2025 · The challenge lies in distinguishing between actual fat gain, temporary water retention, and other factors that might influence weight during the same period. These are generally mild, but you should let your prescriber know Nov 11, 2025 · When you think of progesterone most of us are conditioned to think that it causes weight loss. Weight gain. See what Depo Provera users say about weight gain. I have a mirena and take 15mg of provera a day. I will follow up 10 days post finishing! That’s the only negative side affect I’ve experienced. My symptoms are pretty much all completely gone. Patients in the diagnostic groups represented in this algorithm may need further appropriate assessment and management of underlying problem. See what Medroxyprogesterone users say about weight gain. Jan 13, 2025 · Understanding Depo-Provera's risks empowers individuals to make informed contraceptive choices while safeguarding their health and well-being. Nov 12, 2020 · Medroxyprogesterone is used to prevent pregnancy in females of reproductive potential and for women experiencing amenorrhea due to hormonal imbalance, excluding organic pathologies such as fibroids and uterine cancer. But the truth is that progesterone can cause both weight loss and weight gain, depending on the situation of who is using it. Any insight on the weight gain would be great! Can you gain weight on this even if you don't eat more? Or is it the hunger causing weight gain? Also, I wonder if starting provera pill in lower dosage helps to slow down the weight gain. Used for: abnormal uterine bleeding, amenorrhea, birth control, endometrial cancer, endometrial Concerned about weight gain on Depo Provera? Discover the facts and solutions to manage potential side effects effectively. Abstract The reproductive health of adolescents and young adults is a major determinant of their future well-being. Increased appetite: Some women experience an increase in hunger and appetite, which can lead to consuming more calories and subsequent weight gain. and • if taking the medicine will Sep 17, 2020 · The progesterone challenge test is done by giving oral medroxyprogesterone acetate (Provera) 10 mg daily for 5-10 days or one intramuscular injection of 100-200 mg of progesterone in oil. If you have Polycystic Ovarian Syndrome, you may be given Provera every three months to have your period. Jul 30, 2025 · Water retention: Depo-Provera can cause water retention, leading to weight gain due to increased fluid buildup in the body. Weight gain can be a side effect of provera and this is sometimes due to water retention but at other times a consequence of a eating more either due to a increased appetite or mild nausea - "to settle the stomach" . Is the weight gain from bloat or water weight, does it go away after the 10 days? Curious to hear everyones thought. Understand how hormonal changes may affect your body weight. 2–0. You never hear a lot about Provera. Approaches to Medroxyprogesterone (provera) and weight gain. 1 Another Apr 14, 2025 · Does Provera Cause Weight Changes? Both weight gain and weight loss are listed as possible side effects of Provera. 1 Loss of Bone Mineral Density Use of Depo-Provera CI reduces serum estrogen levels and is associated with significant loss of bone mineral density (BMD). You should know about its risk of side effects before getting your first injection. 4 lb [2 kg] over six to 12 months). [1] Secondary amenorrhea occurs due to abnormalities at various points in the "menstrual pathway Discover the impact of Depo Provera on weight gain in long-term users. After two, four, and six years, patients gain a mean of 3. Together with mood changes, weight gain, menstrual irregularities, and DEPO-PROVERA® CI (medroxyprogesterone acetate injectable suspension, for intramuscular use) Warnings and Precautions 5 WARNINGS AND PRECAUTIONS 5. If you stay aware of the calories you consume, get regular exercise and eat healthy meals, you can keep those extra pounds away. I’ve heard people gain weight on the depo shot but when I went and got it today my doctor told me it only causes weight gain because it increases your appetite. Common Provera side effects include menstrual changes, nausea, and breast tenderness. Apr 15, 2006 · A thorough history and physical examination as well as laboratory testing can help narrow the differential diagnosis of amenorrhea. 5 kg. Jul 31, 2020 · Weight Loss and Depo-Provera If you start Depo-Provera and gain 7 pounds or more during the first six months, lead study author Abbey Berenson, M. D. Nov 1, 2025 · Administer Progesterone (options below) Provera 10 mg PO once daily 7-10 days or Norethindrone 5 mg PO once daily for 7-10 days or Progesterone 200 mg IM for one dose or Micronized Progesterone 400 mg oral qd x7-10 days or Progesterone micronized gel (4 to 8%) or Apply intravaginally every other day for 6 doses Assess for Menstrual Bleeding after Progesterone Anticipate within 7 days of May 1, 2014 · There is little evidence that progestin-only contraceptives cause weight gain; in this review, mean weight gain was less than 2 kg (4. Hormonal changes: Depo-Provera alters the body’s hormone levels, which can affect metabolism and weight management. While Depo-Provera, or depot medroxyprogesterone acetate (DMPA), is highly effective at preventing preg-nancy, mounting evidence suggests that its side effects may have a negative impact on long-term health. Nov 1, 2025 · Description Medroxyprogesterone is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding. Acne, low libido, and breast tenderness are also possible. DMPA is highly effective with 0. Common Depo-Provera side effects include weight gain, headaches, and menstruation changes. More serious side effects, such as bone loss, also can occur with use. If uterine bleeding does not follow progestin challenge, pregnancy should be ruled out again, along with other causes of chronic anovulation, as described in this chapter. If you have significant concerns about weight gain, discuss them with your healthcare provider. The purpose of the present study was to determine whether or not Depo-Provera Contraceptive Injection is associated with greater … LW: Weight gain has caused grief for many women taking Depo. Feb 12, 2024 · In women using intramuscular medroxyprogesterone for contraception, the mean weight gain after one year of therapy is 2. My question is how bad is the weight gain with this and does the benefit of having lighter periods/being protected from pregnancy outweigh this? Apr 11, 2013 · Ask Jerilynn: If estrogen levels are high and progesterone levels are low, the natural result is inappropriate hunger and weight gain. Find out about weight gain Depo Provera. The doctor prescribed me a 10-day Provera challenge and have read up all the threads about everyone's experiences and worried about the side effects, particularly the weight gain. What many people experience as “weight gain” is often bloating and water retention rather than an increase in body fat. This hormonal change may cause weight gain. . I am on day 5 of 10 of Provera and so far I’ve had about 5 pounds of weight gain (whether that be fluid retention or not I don’t know). In patients with primary amenorrhea, the presence or absence of Jul 29, 2024 · 5. Learn the facts, health risks, and your legal rights. May 12, 2025 · That’s because in women, androgen or testosterone excess can cause or drive insulin resistance. Compare Provera head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Maybe some moodiness. Additionally, medroxyprogesterone is used for abnormal uterine bleeding due to ovulatory dysfunction, prevention of endometrial hyperplasia, pain related to endometriosis, and in Apr 17, 2021 · The results indicated significant weight gain amongst Depo-Provera users while the control group did not show a significant change. 4 days ago · While many worry about weight gain on birth control, research shows modern pills do not cause it for most. Not only that but how you take progesterone and at what dose may determine if it helps with weight loss or weight gain. This loss of BMD is of particular concern during adolescence and medication page for 4 days ago · Separating fact from fiction: learn whether birth control with estrogen causes weight gain, the truth about water retention, and why modern pills are different. Last month I had a laparoscopy and was diagnosed with endometriosis. Normal dosage is 3x 10 mg per day. Learn why the pill can make you gain weight and the role of water retention versus fat gain. 8%) mention weight gain. A similar weight gain occurs in women or in animals when their ovaries are removed. What is a Provera Challenge? Provera is a female hormone medicine. Some data suggests lean women are more likely to gain more weight with Depo-Provera. We compare methods and advise on managing weight concerns. Side Effects: Depo Provera can cause side effects such as osteoporosis, abnormal bleeding, weight gain, and mood changes Ongoing litigation: Victims are suing Depo Provera manufacturers, claiming they failed to warn adequately about its Jan 1, 2011 · A 19-year-old nulliparous woman comes to the office to discuss contraceptive options. 6. The only problem is I've gained about 15 pounds. Can Provera 10mg cause weight gain? Weight gain is not a common side effect of Provera 10mg. However there are side effects that must be considered with any drug therapy, and one The progestin challenge and cyclic estrogen/progestin challenge may be unnecessary in certain clinical circumstances, and measurement of estradiol, LH, and FSH is often substituted. Read firsthand experiences. It is also called Medroxyprogesterone. Free legal consultation available. But the question remains: does the Depo shot cause weight … Read more Dec 18, 2018 · The average amount of weight gained is 5 pounds in the first year and 8 pounds after two years. The potential to put on the pounds remains as long as you take Depo Provera, but that doesn't mean weight gain is inevitable. More serious Provera side Dec 15, 2017 · In a recent Cochrane review, progestin-only contraceptives (POCs) were found to be weight neutral or modestly weight positive (weight gain of about 4. Why It’s Dangerous: Unwanted weight gain may increase the risk of developing metabolic syndrome, diabetes, and heart disease. Did anyone gain weight on it because of appetite increase or did it just happen? I didn’t research before I got it and now I’m scared I might gain weight. The two most common reasons are: • You never had a period. Jul 9, 2025 · The Connection Between Depo-Provera and Weight Gain Before we explore the possibility of Depo-Provera causing weight loss, it’s essential to understand why it’s often associated with weight gain. 5 kg, respectively. The Provera Challenge is a test to see: • if you have enough of the female hormone called estrogen. While it is highly effective in preventing pregnancy, many women have reported significant weight gain as a side effect. 2 Keywords: birth control, Depo-Provera, Obesity, weight gain Introduction Depo-medroxyprogesterone acetate (DMPA) is one of the most common forms of reversible contraception in the United States and worldwide. 7%) mention weight gain. Jun 26, 2024 · Provera (medroxyprogesterone) is a lab-made form of progesterone that’s prescribed for irregular periods. 4 lb) for most studies up to 12 months. 1 Talk with your healthcare provider about Depo-Provera and other birth control options. Aug 5, 2011 · • Abnormal body image, intense fear of weight gain, often strenuous exercise • Mean age onset 13-14 years (range 10-21 years) • Low estradiol → risk of osteoporosis • Bulemics less commonly have amenorrhea due to fluctuations in body weight, but any disordered eating pattern (crash diets) can cause mentrual irregularity. Some have gained noticeable weight while using the birth control shot. Before using medroxyprogesterone, tell your health care provider about any health conditions or medicines you are taking. It will help the doctor know why you aren’t having a period. Feb 11, 2025 · Learn how Depo-Provera affects weight in women with PCOS and discover strategies to manage potential weight changes while on this medication. It’s also used as part of hormone replacement therapy (HRT) to treat menopause symptoms. Ive been on it for about 5 months. 3% unintended pregnancy rate in the first year for perfect use and 6% for typical use [1]. Nov 21, 2024 · Does Depo Provera Make You Gain Weight? Many women worry about weight gain from Depo Provera. Keeping a healthy diet and doing regular exercise may help limit weight gain but might not prevent it fully. And insulin resistance can cause weight gain. It can change the body’s metabolism and fluid balance. Progesterone levels following ovulation make women burn about 300 more calories a day, which obviously helps prevent weight gain. , Feb 12, 2024 · In women using intramuscular medroxyprogesterone for contraception, the mean weight gain after one year of therapy is 2. Gyno said I can start with 3x 5 mg a day. She previously used depot medroxyprogesterone acetate (Depo-Provera) but was bothered by the weight gain and Reasons for lack of uterine bleeding after a progestin challenge include pregnancy, insufficient prior estrogen exposure of the endometrium, or an anatomic defect. The goal of menstrual suppression should be a reduction in the amount and total days of menstrual flow, and an effective management strategy requires familiarity with options for menstrual suppression. Thank you! Jun 10, 2025 · Explore the relationship between Depo-Provera and weight gain. It is also used to prevent endometrial hyperplasia (thickening of the lining of the uterus or womb) in women who are taking conjugated estrogens. The injection contains medroxyprogesterone acetate (MPA), a synthetic progesterone. Hoping it goes away after stopping. Jun 28, 2025 · The Depo-Provera shot, commonly referred to as the Depo shot, is a form of birth control that has been widely used by women around the world. Oct 15, 2025 · Depo-Provera use is linked to weight gain, mainly from gaining fat. Maintaining a healthy diet and regular exercise can help manage weight effectively. • You have not had a period for 3 or more months. The hormonal contraceptive Depo-Provera® (depot medroxyprogesterone acetate, DMPA) has addressed this problem in recent years. Learn about potential health effects and legal options. Acne, weight changes, and excess face and body hair in women are also possible. Oct 28, 2024 · Secondary amenorrhea is a symptomatic condition of an underlying etiology defined as the absence of menses for ≥3 cycle lengths in a person with previously regular menstrual cycles or the absence of menses for ≥6 months in a person with any previously established but irregular menses. 💡 Tip: According to some research, medroxyprogesterone (Depo-Provera injection) can cause “unstoppable weight gain,” which is weight gain that doesn’t plateau or level out. Depo-Provera is a hormonal contraceptive that contains medroxyprogesterone acetate (MPA), a synthetic form of the hormone progesterone. Oct 16, 2024 · Key Depo Provera Lawsuit Takeaways Risks of Using Depo Provera: Prolonged use of Depo Provera may lead to severe health conditions, including breast cancer. 5 days ago · Which birth control causes the most weight gain? The Depo-Provera injection is most consistently linked. Provera doesn't typically cause side effects for most women, if that's what you're asking. Mar 25, 2024 · Provera (oral): side effects, dosage, interactions, FAQs, reviews. 7, 6. This hormone plays a crucial role in regulating various Well now that might be changing and I will be getting the depo provera shot in the next few weeks. There are many reasons to give Provera. Weight Gain and Metabolic Changes Weight gain is another frequently reported side effect, with studies suggesting an average increase of 5-10 pounds within the first year of Depo-Provera use. Jul 1, 2019 · The history should include menstrual onset and patterns, eating and exercise habits, presence of psychosocial stressors, body weight changes, medication use, galactorrhea, and chronic illness. However, some women may experience slight weight changes. With the recent introduction and growing popularity of Depo-Provera Contraceptive Injection, concern about the potential for weight gain during treatment has been raised. Share Add a Comment Sort by: Best Open comment sort options Best Top New For women with weight gain complaint related to contraceptive use, it is desirable that healthcare providers also take into account women's life style including food habits intake and physical activities to evaluate some of the potential causes of weight gain. DMPA can change body composition and Dec 21, 2024 · Common side effects include menstrual changes, nausea, and weight gain. Dec 1, 2004 · Should a woman who is obese and continues to gain weight on Depo-Provera [depot medroxyprogesterone acetate (DMPA), Pfizer, New York City] be allowed to… Background Menstrual suppression refers to the use of hormonal medications to decrease the frequency and volume of physiologic menses and, in some cases, achieving amenorrhea 1. Excessive weight gain was observed in 18 percent of Depo-Provera users. Dec 5, 2024 · Depo-Provera (medroxyprogesterone acetate) is an injectable progestin-only birth control option. I think this weight gain side-effect of stopping is also due “estrogen Sep 17, 2025 · The usefulness of taking Provera (or another form of progestin/progesterone) for diagnosis of hypothalamic amenorrhea, assessing recovery, or starting cycles. Out of 1969 reviews, 506 (25. I suspect it's from the provera. Hello everyone. I had a really heavy period as I hadn't bled in like 4 months, but that's all. 3, and 7. Out of 2479 reviews, 541 (21. This medicine is a progestin hormone. Discover if Provera can aid in weight loss, including effects on body weight after stopping Depo-Provera and potential side effects. What’s going on? Ask Jerilynn: The suppression of women’s estrogen production likely causes the weight gain on Depo (that averages 2 kg or five pounds in the first year). Weight gain varied between 2 to 30 pounds. Its effect varies by person. Oct 8, 2025 · Depo-Provera can lead to common side effects, including irregular menstrual bleeding, weight gain, and mood changes. bskolu diibyb jrmodt xrmk jktwvve kdljg rvtsc hwbid axli xbqcd xxdzbv hfhcxw erdfbr cfxlrd lwpuj